New approach shows promise in treating antidepressant-resistant depression

Depression affects about 121 million people worldwide, with about 10 percent of all cases involving individuals who do not respond to antidepressants, according to an approximation by the U.S. Food and Drug Administration. UF researchers examined two kinds of rat models, including one that s very sensitive to pressure and exceptionally resistant to antidepressant treatments to uncover alternatives to this issue. Researchers surmised the anxiety-prone rats brains might have greater quantities of a protein that could play a part in depression, said Darragh P. Devine, Ph.D., the study s lead author and a professor of behavioral and cognitive neuroscience in the UF College of Liberal Arts and Sciences department of psychology and the College of Medicine section of neuroscience. The research was published in the journal Pharmacology, Biochemistry and Behavior. The pressure-sensitive rats which were exposed to severe and long-term anxiety had higher amounts of the protein, organic cation tr
https://www.ptsdnews.com/new-approach-shows-promise-in-treating-antidepressant-resistant-depression/32/